There is a realm in which the most acute and most experienced of detectives is helpless.
Arthur Conan Doyle, The Hound of Baskervilles
Their evidence, corroborated by that of several friends, tends to show that Sir Charles’s health has for some time been impaired, and points especially to some affection of the heart, manifesting itself in changes of colour, breathlessness, and acute attacks of nervous depression.
Arthur Conan Doyle, The Hound of Baskervilles
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Dictionary
Merriam-Webster
— characterized by sharpness or severity of sudden onset
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Macmillan
— very serious or severe
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Usage
2 uses of ‘acute’ in The Hound of the Baskervilles, by Arthur Conan Doyle